High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma.

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作者： Youyou,Xie ^[1] ; Dongqing,Lv ^[2] ; Wei,Wang ^[3] ; Minhua,Ye ^[1] ; Xiaofeng,Chen ^[2] ; Haihua,Yang ^[4]

作者单位： Laboratory of Cellular and Molecular Radiation Oncology, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, 317000, Zhejiang Province, China. ^[1] Department of Radiation Oncology, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, 317000, Zhejiang Province, China. ^[2] Department of Pulmonary Medicine, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, 317000, Zhejiang Province, China. ^[3] Department of Thoracic Surgery, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, 317000, Zhejiang Province, China. ^[4] Enze Medical Research Center, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, 317000, Zhejiang Province, China. ^[5]

关键词 PH domain leucine-rich-repeats protein phosphatase acquired resistance epidermal growth factor receptor tyrosine kinase inhibitor lung adenocarcinoma

DOI 10.18632/oncotarget.19777

PMID 28938613

发布时间 2018-11-13

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