Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles.

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作者： Guangsheng,Du ^[1] ; Rania M,Hathout ^[2] ; Maha,Nasr ^[2] ; M Reza,Nejadnik ^[1] ; Jing,Tu ^[3] ; Roman I,Koning ^[4] ; Abraham J,Koster ^[4] ; Bram,Slütter ^[5] ; Alexander,Kros ^[3] ; Wim,Jiskoot ^[1] ; Joke A,Bouwstra ^[6] ; Juha,Mönkäre ^[1]

作者单位： Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. ^[1] Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. ^[2] Department of Supramolecular & Biomaterials Chemistry, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands. ^[3] Department of Molecular Cell Biology, Section Electron Microscopy, Leiden University Medical Center, Leiden University, Leiden, The Netherlands. ^[4] Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Division of Biopharmaceutics, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. ^[5] Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address: bouwstra@lacdr.leidenuniv.nl. ^[6]

关键词 Adjuvant Antigen Hollow microneedles Intradermal vaccination Nanoparticles