换一批Development of a subunit vaccine for prevention of <i>Clostridium difficile</i> associated diseases: Biophysical characterization of toxoids A and B.
第一作者：
Alexey,Gribenko
第一单位：
Pfizer Vaccine Research and Development, 401 N. Middletown Road, Pearl River, NY 10965, USA.
作者：
关键词
ANS, 1-anilinonaphtalene-8-sulfonic acidBiophysical characterizationC. difficileCD, circular dichroism spectroscopyDSC, differential scanning calorimetryEDC, 1-ethyl-3-[3–dimethylaminopropyl]carbodiimide hydrochlorideNHS, N-hydroxysulfosuccinimidePBS, Phosphate buffered salinePM TcdB, D286A/D288A/C698A/E970K/E976K toxin B penta mutantSubunit vaccineTM TcdA, D285A/D287A/C700A toxin A triple mutantTM TcdB, D286A/D288A/C698A toxin B triple mutantTcdA, wild type toxin ATcdB, wild type toxin BToxins/toxoids A and BTxdA, EDC/NHS-treated D285A/D287A/C700A toxoid A triple mutantTxdB, EDC/NHS-treated D286A/D288A/C698A toxoid B triple mutant
DOI
10.1016/j.bbrep.2016.12.015
PMID
28956005
发布时间
2020-09-30
- 浏览13
Biochemistry and biophysics reports
2017年9卷
193-202页
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