作者：
Natsuko,Saito [1]
;
Shunsuke,Kimura [2]
;
Tomomi,Miyamoto [3]
;
Sanae,Fukushima [4]
;
Misato,Amagasa [1]
;
Yoshinori,Shimamoto [5]
;
Chieko,Nishioka [4]
;
Shiki,Okamoto [6]
;
Chitoku,Toda [7]
;
Kohei,Washio [1]
;
Atsushi,Asano [8]
;
Ichiro,Miyoshi [3]
;
Eiki,Takahashi [4]
;
Hiroshi,Kitamura [1]
作者单位：
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, and Laboratory of Animal Therapeutics, Japan.
[1]
Laboratory of Histology and Cytology, Department of Functional Morphology, Graduate School of Medical Sciences, Hokkaido University, Kita15, Nishi7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan.
[2]
Department of Comparative and Experimental Medicine, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
[3]
Research Resources Center, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
[4]
Department of Veterinary Science, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu, Hokkaido 069-8501, Japan.
[5]
Division of Endocrinology and Metabolism, National Institute for Physiological Sciences, 38 Nishigonaka Myodaiji, Okazaki, Aichi 444-8585, Japan.
[6]
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8063, USA.
[7]
Laboratory of Laboratory Animal, Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
[8]
关键词
DMEM, Dulbecco's modified Eagle mediumDiabetesELISA, enzyme-linked immunosorbent assayGAPDH, glyceraldehyde 3-phosphate dehydrogenaseHFD, high-fat dietHOMA-IR, homeostatic model assessment as an index of insulin resistanceIL, interleukinIR, insulin receptorIRS, insulin receptor substrateInsulinKD, knock downKO, knockoutMacrophageNCD, normal chow dietNEFA, nonesterified fatty acidObesityPDK, phosphoinositide-dependent kinasePI3K, phosphatidylinositol 3-phosphate kinaseSOCS, suppressor of cytokine signalingT2DM, type 2 diabetes mellitusTg, transgenicUSPUSP, ubiquitin-specific proteasepAkt, phosphorylated AktpIRβ, phosphorylated insulin receptor β chain
DOI
10.1016/j.bbrep.2017.01.009
PMID
28956020
发布时间
2020-09-30
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