换一批Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1<i>H</i>-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1<i>H</i>-pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione.
第一作者：
Donald S,Karanewsky
第一单位：
Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States.
作者：
关键词
AUC, area under the curveCL, plasma clearanceCYP, cytochrome P450Cmax, peak plasma concentrationFDA, Food and Drug AdministrationFEMA GRASFEMA, Flavour and Extract Manufacturers Association of the United StatesGLP, Good Laboratory PracticesGMP, good manufacturing practicesGPCR, G protein-coupled receptorsGenetic toxicological evaluationHPBL, human peripheral blood lymphocytesJECFA, Joint FAO/WHO Expert Committee on Food AdditivesLC/MS, liquid chromatography with mass spectrometryMC, methylcelluloseMRM, multiple-reaction monitoringMSDI, maximized survey-derived intakeMTD, maximum tolerated doseNOAEL, no-observed-adverse-effect-levelNOEL, no-observed-effect-levelOECD, Organization for Economic Cooperation and DevelopmentPCE, polychromatic erythrocytesPK, pharmacokineticsS6821S7958SPET, single portion exposure techniqueSubchronic toxicological evaluationTE, total erythrocytesTK, toxicokineticsTmax, time to reach CmaxVss, volume of distribution at steady-statemnPCE, micronucleated bone marrow polychromatic erythrocytest1/2, half-life
DOI
10.1016/j.toxrep.2016.02.007
PMID
28959552
发布时间
2024-06-04
- 浏览4
Toxicology reports
2016年3卷
310-327页
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