换一批Toxicological evaluation and metabolism of two <i>N</i>-alkyl benzamide umami flavour compounds: <i>N</i>-(heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide and (<i>R</i>)-<i>N</i>-(1-methoxy-4-methylpentan-2-yl)-3,4-dimethylbenzamide.
第一作者：
Donald S,Karanewsky
第一单位：
Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States.
作者：
关键词
AUC, area under the curveCL, plasma clearanceCOMT, catechol-O-methyltransferaseCmax, peak plasma concentrationFDA, Food and Drug AdministrationFEMA GRASFEMA, Flavour and Extract Manufacturers Association of the United StatesFL-no, FLAVIS numberGLP, good laboratory practicesGMP, good manufacturing practicesGenetic toxicological evaluationHPBL, human peripheral blood lymphocytesLC/MS, liquid chromatography with mass spectrometryMC, methylcelluloseMRM, multiple-reaction monitoringMSG, monosodium glutamateMTD, maximum tolerated doseNOAEL, no-observed-adverse-effect-levelNOEL, no-observed-effect-levelOECD, Organization for Economic Cooperation and DevelopmentPK, pharmacokineticsRCG, relative cell growthRMI, relative mitotic indexS807S9229Subchronic toxicological evaluationTK, toxicokineticsTmax, time to reach CmaxVss, volume of distribution at steady-stateamu, atomic mass unitst1/2, half-life
DOI
10.1016/j.toxrep.2016.10.008
PMID
28959612
发布时间
2020-09-30
- 浏览12
Toxicology reports
2016年3卷
841-860页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
