Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.

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作者： Masayuki,Yamaji ^[1] ; Akinobu,Ota ^[2] ; Md,Wahiduzzaman ^[2] ; Sivasundaram,Karnan ^[2] ; Toshinori,Hyodo ^[2] ; Hiroyuki,Konishi ^[2] ; Shinobu,Tsuzuki ^[2] ; Yoshitaka,Hosokawa ^[2] ; Masayuki,Haniuda ^[2]

作者单位： Division of Chest Surgery, Department of Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan. ^[1] Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan. ^[2]

关键词 Afuresertib Akt inhibitor Mesothelioma cancer therapy

主题词抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);苄胺类(Benzylamines);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);半胱氨酸天冬氨酸蛋白酶7(Caspase 7);细胞系, 肿瘤(Cell Line, Tumor);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);杂环化合物, 3环(Heterocyclic Compounds, 3-Ring);人类(Humans);咪唑类(Imidazoles);半数抑制浓度(Inhibitory Concentration 50);间皮瘤(Mesothelioma);恶二唑类(Oxadiazoles);磷酰化(Phosphorylation);磷酰胆碱(Phosphorylcholine);胸膜肿瘤(Pleural Neoplasms);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);吡唑类(Pyrazoles);吡啶类(Pyridines);嘧啶类(Pyrimidines);吡咯类(Pyrroles);喹恶啉类(Quinoxalines);磺胺类(Sulfonamides);噻二唑类(Thiadiazoles);噻吩类(Thiophenes)

DOI 10.1002/cam4.1179

PMID 28960945

发布时间 2021-01-09

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Cancer medicine

2017年6卷11期

2646-2659页

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Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.

Cancer medicine

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Cancer medicine

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Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.

Cancer medicine

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Cancer medicine

相关期刊

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