A novel aromatic mutagen, 5-amino-6-hydroxy-8<i>H</i>-benzo[6,7]azepino[5,4,3-<i>de</i>]quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice.

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作者： Takahiro,Kochi ^[1] ; Masahito,Shimizu ^[1] ; Yukari,Totsuka ^[2] ; Yohei,Shirakami ^[1] ; Takayuki,Nakanishi ^[1] ; Tetsushi,Watanabe ^[3] ; Takuji,Tanaka ^[4] ; Hitoshi,Nakagama ^[2] ; Keiji,Wakabayashi ^[5] ; Hisataka,Moriwaki ^[1]

作者单位： Department of Internal Medicine/Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. ^[1] Division of Cancer Development System, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan. ^[2] Department of Public Health, Kyoto Pharmaceutical University, 1 Shichono-cho, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. ^[3] Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. ^[4] Division of Nutritional and Environmental Sciences, Institute for Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ^[5]

关键词 ABAQ, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one AOM, azoxymethane Benzoazepinoqunolinone Colon DSS, dextran sodium sulfate Dextran sodium sulfate Fenton reaction H&E, hematoxylin and eosin HCA, heterocyclic amine Heterocyclic amines High-grade dysplasia Initiation Maillard reaction MeIQx, 2-amino-3,8-dimethylimidazo[4,5-flquinoxaline Mice PAH, polycyclic aromatic hydrocarbons PDCD4 PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine i.g, intragastric

DOI 10.1016/j.toxrep.2014.04.006

PMID 28962227

发布时间 2020-09-30

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Toxicology reports

2014年1卷

69-73页

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A novel aromatic mutagen, 5-amino-6-hydroxy-8<i>H</i>-benzo[6,7]azepino[5,4,3-<i>de</i>]quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice.

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A novel aromatic mutagen, 5-amino-6-hydroxy-8<i>H</i>-benzo[6,7]azepino[5,4,3-<i>de</i>]quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice.

Toxicology reports

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Toxicology reports

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