换一批A peripherally restricted P2Y<sub>12</sub> receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism.
第一作者：
David A,Brott
第一单位：
Drug Safety & Metabolism, AstraZeneca Pharmaceuticals, R&D, Wilmington, DE, USA.
作者：
关键词
ADP, adenosine-5′-diphosphateAUC, area under the curveCHO, Chinese hamster ovaryCarcinogenicityCmax, maximal concentration, DAT, dopamine transportDopamine transport inhibitorE2, estradiolGLP, good laboratory practiceH&E, hematoxylin and eosinIC50, inhibitory concentration fifty percentKi, inhibition concentrationLC-MS/MS, liquid chromatography-mass spectrometricLLOQ, lower limits of quantificationMOA, mode of actionMTD, maximum tolerated doseNH, Hill coefficientProlactinQWBA, quantitative whole body autoradiographyTK, toxicokineticsTranslationalUterine tumor
DOI
10.1016/j.toxrep.2014.11.010
PMID
28962330
发布时间
2020-09-30
- 浏览5
Toxicology reports
2014年1卷
1202-1212页
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