Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity.

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作者： Simone,Carradori ^[1] ; Bruna,Bizzarri ^[2] ; Melissa,D'Ascenzio ^[2] ; Celeste,De Monte ^[2] ; Rossella,Grande ^[3] ; Daniela,Rivanera ^[4] ; Alessanda,Zicari ^[5] ; Emanuela,Mari ^[5] ; Manuela,Sabatino ^[6] ; Alexandros,Patsilinakos ^[7] ; Rino,Ragno ^[7] ; Daniela,Secci ^[8]

作者单位： Department of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy. Electronic address: simone.carradori@unich.it. ^[1] Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. ^[2] Department of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy; Center for Aging Science and Translational Medicine (CeSI-MeT), Via dei Vestini 31, 66100 Chieti, Italy. ^[3] Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. ^[4] Dipartimento di Medicina Sperimentale, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. ^[5] Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy; Rome Center for Molecular Design, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. ^[6] Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy; Rome Center for Molecular Design, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy; Alchemical Dynamics s.r.l., 00125 Rome, Italy. ^[7] Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. Electronic address: daniela.secci@uniroma1.it. ^[8]

关键词 3-D QSAR Antifungal activity Candida spp.Cytotoxicity Thiazolidinone