Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1.

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作者： Anurag,Kulkarni ^[1] ; Manuel,Mateus ^[1] ; Cyrille C,Thinnes ^[2] ; James S,McCullagh ^[2] ; Christopher J,Schofield ^[2] ; Graham P,Taylor ^[1] ; Charles R M,Bangham ^[3]

作者单位： Section of Virology, Department of Medicine, Imperial College, London W2 1PG, UK. ^[1] Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, UK. ^[2] Section of Virology, Department of Medicine, Imperial College, London W2 1PG, UK. Electronic address: c.bangham@imperial.ac.uk. ^[3]

关键词 2-oxoglutarate HIF hydroxylase HTLV-1 epigenetic regulation glucose hypoxia latency metabolism virus

主题词氨基酸类, 二羧酸(Amino Acids, Dicarboxylic);芳香烃受体核转位子(Aryl Hydrocarbon Receptor Nuclear Translocator);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);细胞低氧(Cell Hypoxia);细胞, 培养的(Cells, Cultured);柠檬酸循环(Citric Acid Cycle);电子传递链复合蛋白质类(Electron Transport Chain Complex Proteins);后成说, 遗传(Epigenesis, Genetic);葡萄糖(Glucose);糖酵解(Glycolysis);组蛋白类(Histones);人类嗜T淋巴细胞病毒1型(Human T-lymphotropic virus 1);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);酮戊二酸类(Ketoglutaric Acids);白细胞, 单核(Leukocytes, Mononuclear);线粒体(Mitochondria);氧(Oxygen);病毒潜伏期(Virus Latency);病毒复制(Virus Replication)

DOI 10.1016/j.chembiol.2017.08.016

PMID 28965728

发布时间 2022-01-29

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Cell chemical biology

2017年24卷11期

1377-1387.e3页

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Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1.

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Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1.

Cell chemical biology

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