Inhibition of the sarco/endoplasmic reticulum (ER) Ca<sup>2+</sup>-ATPase by thapsigargin analogs induces cell death via ER Ca<sup>2+</sup> depletion and the unfolded protein response.

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第一作者： Pankaj,Sehgal

第一单位： From the Department of Biomedicine, Aarhus University, DK-8000 Aarhus, Denmark.

作者： Pankaj,Sehgal ^[1] ; Paula,Szalai ^[2] ; Claus,Olesen ^[3] ; Helle A,Praetorius ^[4] ; Poul,Nissen ^[1] ; Søren Brøgger,Christensen ^[3] ; Nikolai,Engedal ^[1] ; Jesper V,Møller ^[3]

作者单位： From the Department of Biomedicine, Aarhus University, DK-8000 Aarhus, Denmark. ^[1] Biology Platform, Sunnybrook Research Institute, and Department of Biochemistry, University of Toronto, Toronto, Ontario M4N 3M5, Canada. ^[2] Centre for Membrane Pumps in Cells and Disease (Pumpkin), Danish Research Foundation, DK-8000 Aarhus, Denmark. ^[3] Centre for Molecular Medicine Norway (NCMM), Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine, University of Oslo, P. O. Box 1137 Blindern, 0318 Oslo, Norway. ^[4] Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic EMBL Partnership for Molecular Medicine, Department of Molecular Biology and Genetics, DK-8000 Aarhus, Denmark, and. ^[5] Department of Drug Design and Pharmacology, University of Copenhagen, DK-2100 Copenhagen, Denmark. ^[6] Centre for Molecular Medicine Norway (NCMM), Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine, University of Oslo, P. O. Box 1137 Blindern, 0318 Oslo, Norway, k.n.engedal@ncmm.uio.no. ^[7] From the Department of Biomedicine, Aarhus University, DK-8000 Aarhus, Denmark, jvm@biomed.au.dk. ^[8]

关键词 apoptosis calcium endoplasmic reticulum (ER)stromal interaction molecule 1 (STIM1)unfolded protein response (UPR)