Mathematical modeling of white adipocyte exocytosis predicts adiponectin secretion and quantifies the rates of vesicle exo- and endocytosis.

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作者： Cecilia,Brännmark ^[1] ; William,Lövfors ^[2] ; Ali M,Komai ^[1] ; Tom,Axelsson ^[3] ; Mickaël F,El Hachmane ^[1] ; Saliha,Musovic ^[1] ; Alexandra,Paul ^[4] ; Elin,Nyman ^[5] ; Charlotta S,Olofsson ^[6]

作者单位： Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Medicinaregatan 11, SE-405 30 Göteborg. ^[1] Departments of Biomedical Engineering, SE-581 83 Linköping; Mathematics, Linköping University, SE-581 83 Linköping. ^[2] Departments of Biomedical Engineering, SE-581 83 Linköping. ^[3] Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10 SE-412 96 Göteborg. ^[4] Departments of Biomedical Engineering, SE-581 83 Linköping; Cardiovascular and Metabolic Diseases iMed Biotech Unit, AstraZeneca R&D, 431 83 Gothenburg, Sweden. Electronic address: elin.nyman@liu.se. ^[5] Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Medicinaregatan 11, SE-405 30 Göteborg. Electronic address: charlotta.olofsson@gu.se. ^[6]

关键词 adipocyte adipokine adiponectin electrophysiology endocytosis exocytosis mathematical modeling