p-Alkyl-Benzoyl-CoA Conjugates as Relevant Metabolites of Aromatic Aldehydes With Rat Testicular Toxicity-Studies Leading to the Design of a Safer New Fragrance Chemical.

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第一作者： Heike,Laue

第一单位： Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, CH-8600 Duebendorf, Switzerland.

作者： Heike,Laue ^[1] ; Susanne,Kern ^[1] ; Remo P,Badertscher ^[1] ; Graham,Ellis ^[2] ; Andreas,Natsch ^[1]

作者单位： Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, CH-8600 Duebendorf, Switzerland. ^[1] Regulatory Affairs and Product Safety, Givaudan International SA, CH-1214 Vernier, Switzerland. ^[2]

关键词 acyl-CoA benzoic acid fragrance aldehyde male reproductive toxicity metabolism

主题词醛类(Aldehydes);动物(Animals);苯甲酸盐类(Benzoates);生物转化(Biotransformation);细胞, 培养的(Cells, Cultured);辅酶A(Coenzyme A);肝细胞(Hepatocytes);烃类, 芳香(Hydrocarbons, Aromatic);男(雄)性(Male);分子结构(Molecular Structure);香料(Perfume);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);生殖(Reproduction);危险性评估(Risk Assessment);睾丸(Testis);时间因素(Time Factors)

DOI 10.1093/toxsci/kfx178

PMID 28973542

发布时间 2018-07-25

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Toxicological sciences

2017年160卷2期

244-255页

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p-Alkyl-Benzoyl-CoA Conjugates as Relevant Metabolites of Aromatic Aldehydes With Rat Testicular Toxicity-Studies Leading to the Design of a Safer New Fragrance Chemical.

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p-Alkyl-Benzoyl-CoA Conjugates as Relevant Metabolites of Aromatic Aldehydes With Rat Testicular Toxicity-Studies Leading to the Design of a Safer New Fragrance Chemical.

Toxicological sciences

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Toxicological sciences

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