Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy.

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第一作者： Samantha R,De Silva

第一单位： Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, National Institute for Health Research Biomedical Research Centre, Oxford OX3 9DU, United Kingdom.

作者： Samantha R,De Silva ^[1] ; Alun R,Barnard ^[1] ; Steven,Hughes ^[1] ; Shu K E,Tam ^[1] ; Chris,Martin ^[2] ; Mandeep S,Singh ^[1] ; Alona O,Barnea-Cramer ^[1] ; Michelle E,McClements ^[1] ; Matthew J,During ^[3] ; Stuart N,Peirson ^[1] ; Mark W,Hankins ^[4] ; Robert E,MacLaren ^[5]

作者单位： Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, National Institute for Health Research Biomedical Research Centre, Oxford OX3 9DU, United Kingdom. ^[1] Department of Psychology, The University of Sheffield, Sheffield S1 2LT, United Kingdom. ^[2] The Ohio State University, Columbus, OH 43210. ^[3] Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, National Institute for Health Research Biomedical Research Centre, Oxford OX3 9DU, United Kingdom; mark.hankins@eye.ox.ac.uk enquiries@eye.ox.ac.uk. ^[4] Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, National Institute for Health Research Biomedical Research Centre, Oxford OX3 9DU, United Kingdom; mark.hankins@eye.ox.ac.uk enquiries@eye.ox.ac.uk.;Moorfields Eye Hospital, National Institute for Health Research Biomedical Research Centre, London EC1V 2PD, United Kingdom. ^[5]

关键词 gene therapy human melanopsin optogenetics