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Model-Free Linkage Analysis of a Binary Trait.

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第一作者： Wei,Xu

第一单位： Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, M5G 2M9.;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, M5T 3M7.

作者： Wei,Xu ^[1] ; Jin,Ma ^[2] ; Celia M T,Greenwood ^[3] ; Andrew D,Paterson ^[4] ; Shelley B,Bull ^[5]

作者单位： Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, M5G 2M9.;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, M5T 3M7. ^[1] Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. ^[2] Lady Davis Research Institute, Jewish General Hospital, Montréal, QC, Canada, H3T 1E2.;Department of Oncology and Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montréal, QC, Canada, H4A 3T2 and H3A 1A2. ^[3] Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4.;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, M5T 3M7. ^[4] Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60 Murray St., Box 18, Toronto, ON, Canada, M5T 3L9. bull@lunenfeld.ca.;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, M5T 3M7. bull@lunenfeld.ca. ^[5]

关键词 Affected relative pairs (ARP)Affection status GENEHUNTER Genetic heterogeneity Genetic linkage analysis Identity by descent (IBD) sharing Kong and Cox model Likelihood ratio-based linkage model MERLIN Nonparametric linkage (NPL) score Pedigree structure S.A.G.E.