Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.
第一作者:
Daniel J,Urban
第一单位:
NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
作者:
医学主题词
细胞分化(Cell Differentiation);药物发现(Drug Discovery);药物评价, 临床前(Drug Evaluation, Preclinical);酶抑制剂(Enzyme Inhibitors);酶稳定性(Enzyme Stability);荧光(Fluorescence);戊二酸盐类(Glutarates);高通量筛选分析(High-Throughput Screening Assays);组蛋白类(Histones);人类(Humans);异柠檬酸脱氢酶(Isocitrate Dehydrogenase);甲基化(Methylation);模型, 生物学(Models, Biological);单核细胞(Monocytes);突变(Mutation);球形体, 细胞(Spheroids, Cellular)
DOI
10.1038/s41598-017-12630-x
PMID
28986582
发布时间
2019-06-27
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Scientific reports
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