Thyroid stimulating hormone exhibits the impact on LDLR/LDL-c via up-regulating hepatic PCSK9 expression.

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作者： Yingyun,Gong ^[1] ; Yizhe,Ma ^[1] ; Zhengqin,Ye ^[1] ; Zhenzhen,Fu ^[2] ; Panpan,Yang ^[2] ; Beibei,Gao ^[2] ; Wen,Guo ^[2] ; Dandan,Hu ^[2] ; Jingya,Ye ^[2] ; Shuai,Ma ^[2] ; Fan,Zhang ^[2] ; Li,Zhou ^[2] ; Xinyu,Xu ^[2] ; Zhong,Li ^[3] ; Tao,Yang ^[2] ; Hongwen,Zhou ^[4]

作者单位： Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Key Laboratory of Rare Metabolic Diseases, Nanjing Medical University, Nanjing 211166, China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 210023, China. ^[1] Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. ^[2] Key Laboratory of Rare Metabolic Diseases, Nanjing Medical University, Nanjing 211166, China; Jiangsu Province Key Laboratory of Human Functional Genomics, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 211166, China. ^[3] Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Key Laboratory of Rare Metabolic Diseases, Nanjing Medical University, Nanjing 211166, China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 210023, China. Electronic address: drhongwenzhou@njmu.edu.cn. ^[4]

关键词 Low-density lipoprotein cholesterol Proprotein convertase subtilisin kexin 9 Subclinical hypothyroidism Thyroid stimulating hormone