Thermostability of the coating, antigen and immunostimulator in an adjuvanted oral capsule vaccine formulation.

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第一作者： Stephanie,Longet

第一单位： Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 R590, Dublin 2, Ireland.

作者： Stephanie,Longet ^[1] ; Vincenzo,Aversa ^[2] ; Daire,O'Donnell ^[3] ; Joshua,Tobias ^[4] ; Monica,Rosa ^[2] ; Jan,Holmgren ^[4] ; Ivan S,Coulter ^[2] ; Ed C,Lavelle ^[5]

作者单位： Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 R590, Dublin 2, Ireland. ^[1] Sigmoid Pharma Limited, Dublin City University, Invent Centre, Dublin, Ireland. ^[2] Sigmoid Pharma Limited, Dublin City University, Invent Centre, Dublin, Ireland; FOCAS Research Institute, Dublin Institute of Technology, Kevin St., Dublin 8, Ireland. ^[3] University of Gothenburg Vaccine Research Institute (GUVAX), Dept. of Microbiology and Immunology, University of Gothenburg, Box 435, 405 30 Gothenburg, Sweden. ^[4] Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 R590, Dublin 2, Ireland; Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) & Advanced Materials Bio-Engineering Research Centre (AMBER), Trinity College Dublin, Dublin 2, Ireland. Electronic address: lavellee@tcd.ie. ^[5]

关键词 Adjuvant Alpha-Galactosylceramide (KRN 7000) (PubChem CID: 2826713)Capsule Eudragit L30D 55 and Eudragit L100 55 (Alcogum) (PubChem CID: 107665)Kolliphor HS 15 (Solutol(?) HS 15) (PubChem CID: 71311956)Oral delivery Sorbitol (PubChem CID: 5780)Stability study Vaccine