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DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.

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第一作者： Kate Joanne,Howell

第一单位： University Department of Paediatrics, University of Cambridge, UK; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

作者： Kate Joanne,Howell ^[1] ; Judith,Kraiczy ^[2] ; Komal M,Nayak ^[2] ; Marco,Gasparetto ^[3] ; Alexander,Ross ^[4] ; Claire,Lee ^[3] ; Tim N,Mak ^[2] ; Bon-Kyoung,Koo ^[5] ; Nitin,Kumar ^[6] ; Trevor,Lawley ^[6] ; Anupam,Sinha ^[7] ; Philip,Rosenstiel ^[7] ; Robert,Heuschkel ^[8] ; Oliver,Stegle ^[9] ; Matthias,Zilbauer ^[10]

作者单位： University Department of Paediatrics, University of Cambridge, UK; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. ^[1] University Department of Paediatrics, University of Cambridge, UK. ^[2] University Department of Paediatrics, University of Cambridge, UK; Department of Paediatric Gastroenterology, University of Cambridge and Addenbrooke's Hospital, Cambridge, UK. ^[3] University Department of Paediatrics, University of Cambridge, UK; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK. ^[4] Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK. ^[5] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK. ^[6] Institute of Clinical Molecular Biology (IKMB), Kiel University, Kiel, Germany. ^[7] Department of Paediatric Gastroenterology, University of Cambridge and Addenbrooke's Hospital, Cambridge, UK. ^[8] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. Electronic address: stegle@ebi.ac.uk. ^[9] University Department of Paediatrics, University of Cambridge, UK; Department of Paediatric Gastroenterology, University of Cambridge and Addenbrooke's Hospital, Cambridge, UK; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK. Electronic address: mz304@medschl.cam.ac.uk. ^[10]

关键词 Epigenetics Gut Microbiota Human Intestinal Organoids Intestinal Epithelium