Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.

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作者： Sabrina,Khageh Hosseini ^[1] ; Stefanie,Kolterer ^[1] ; Marlene,Steiner ^[1] ; Viktoria,von Manstein ^[1] ; Katharina,Gerlach ^[1] ; Jörg,Trojan ^[2] ; Oliver,Waidmann ^[3] ; Stefan,Zeuzem ^[3] ; Jörg O,Schulze ^[3] ; Steffen,Hahn ^[4] ; Dieter,Steinhilber ^[4] ; Volker,Gatterdam ^[5] ; Robert,Tampé ^[5] ; Ricardo M,Biondi ^[6] ; Ewgenij,Proschak ^[7] ; Martin,Zörnig ^[8]

作者单位： Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Strasse 42-44, D-60596 Frankfurt/Main, Germany. ^[1] Department of Internal Medicine I, University Hospital Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires C1425FQD, Argentina. ^[2] Department of Internal Medicine I, University Hospital Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany. ^[3] Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt/Main, Germany. ^[4] Institute of Biochemistry, Biocenter/Cluster of Excellence-Macromolecular Complexes, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt/Main, Germany. ^[5] Department of Internal Medicine I, University Hospital Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires C1425FQD, Argentina; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. ^[6] Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt/Main, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. ^[7] Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Strasse 42-44, D-60596 Frankfurt/Main, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address: zoernig@gsh.uni-frankfurt.de. ^[8]

关键词 AlphaScreen Camptothecin Camptothecin (PubChem CID: 24360)FUBP1 HCC Irinotecan (PubChem CID: 60838)SN-38 SN-38 (PubChem CID: 104842)Sorafenib (PubChem CID: 216239)Topotecan (PubChem CID: 60700)