Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.-论文-万方医学网

作者： Matthew A,Burchill ^[1] ; Justin A,Roby ^[2] ; Nanette,Crochet ^[3] ; Megan,Wind-Rotolo ^[2] ; Amy E,Stone ^[3] ; Michael G,Edwards ^[4] ; Rachael J,Dran ^[2] ; Michael S,Kriss ^[3] ; Michael,Gale ^[5] ; Hugo R,Rosen ^[1]

作者单位： Division of Gastroenterology and Hepatology, Hepatitis C Center, Department of Medicine, University of Colorado Denver (UCD), Aurora, Colorado, United States of America. ^[1] Center for Innate Immunity and Immune Disease, University of Washington, Seattle, Washington, United States of America. ^[2] Department of Immunology, University of Washington, Seattle, Washington, United States of America. ^[3] Bristol-Myers Squibb, Exploratory Clinical and Translational Research, Lawrenceville, New Jersey, United States of America. ^[4] Bioinfo Solutions LLC, Parker, Colorado, United States of America. ^[5]

主题词老年人(Aged);动物(Animals);抗病毒药(Antiviral Agents);苯丙氮|艹卓|类(Benzazepines);氨甲酸酯类(Carbamates);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);基因表达调控(Gene Expression Regulation);肝炎病毒属(Hepacivirus);丙型肝炎, 慢性(Hepatitis C, Chronic);肝细胞(Hepatocytes);人类(Humans);咪唑类(Imidazoles);免疫, 先天(Immunity, Innate);吲哚类(Indoles);炎症(Inflammation);异喹啉类(Isoquinolines);肝(Liver);男(雄)性(Male);小鼠(Mice);中年人(Middle Aged);吡咯烷类(Pyrrolidines);磺胺类(Sulfonamides);缬氨酸(Valine)

DOI 10.1371/journal.pone.0186213

PMID 29040318

发布时间 2024-07-18

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Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.

PloS one

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Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.

PloS one

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PloS one

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