首页> Proceedings of the National Academy of Sciences of the United States of America> Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.

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第一作者： Tatsuo,Mano

第一单位： Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.

作者： Tatsuo,Mano ^[1] ; Kenichi,Nagata ^[2] ; Takashi,Nonaka ^[3] ; Airi,Tarutani ^[3] ; Tomohiro,Imamura ^[4] ; Tadafumi,Hashimoto ^[5] ; Taro,Bannai ^[1] ; Kagari,Koshi-Mano ^[1] ; Takeyuki,Tsuchida ^[1] ; Ryo,Ohtomo ^[1] ; Junko,Takahashi-Fujigasaki ^[6] ; Satoshi,Yamashita ^[7] ; Yasumasa,Ohyagi ^[8] ; Ryo,Yamasaki ^[4] ; Shoji,Tsuji ^[1] ; Akira,Tamaoka ^[9] ; Takeshi,Ikeuchi ^[10] ; Takaomi C,Saido ^[2] ; Takeshi,Iwatsubo ^[5] ; Toshikazu,Ushijima ^[7] ; Shigeo,Murayama ^[6] ; Masato,Hasegawa ^[3] ; Atsushi,Iwata ^[11]

作者单位： Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. ^[1] Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama 351-0198, Japan. ^[2] Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan. ^[3] Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. ^[4] Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. ^[5] Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital, Tokyo 173-0015, Japan. ^[6] Division of Epigenomics, National Cancer Center Research Institute, Tokyo 104-0045, Japan. ^[7] Department of Neurology and Geriatric Medicine, Ehime University Hospital, Shitsukawa, Toon, Ehime 791-0295, Japan. ^[8] Department of Neurology, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. ^[9] Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 951-8585, Japan. ^[10] Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan; iwata@m.u-tokyo.ac.jp.;Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan. ^[11]

关键词 Alzheimer’s disease BRCA1 DNA repair methylome