换一批
换一批
作者：
Lorna,Kategaya [1]
;
Paola,Di Lello [2]
;
Lionel,Rougé [3]
;
Richard,Pastor [3]
;
Kevin R,Clark [4]
;
Jason,Drummond [5]
;
Tracy,Kleinheinz [5]
;
Eva,Lin [5]
;
John-Paul,Upton [1]
;
Sumit,Prakash [1]
;
Johanna,Heideker [2]
;
Mark,McCleland [1]
;
Maria Stella,Ritorto [2]
;
Dario R,Alessi [1]
;
Matthias,Trost [2]
;
Travis W,Bainbridge [1]
;
Michael C M,Kwok [2]
;
Taylur P,Ma [6]
;
Zachary,Stiffler [6]
;
Bradley,Brasher [7]
;
Yinyan,Tang [8]
;
Priyadarshini,Jaishankar [8]
;
Brian R,Hearn [9]
;
Adam R,Renslo [10]
;
Michelle R,Arkin [10]
;
Frederick,Cohen [11]
;
Kebing,Yu [11]
;
Frank,Peale [11]
;
Florian,Gnad [11]
;
Matthew T,Chang [11]
;
Christiaan,Klijn [4]
;
Elizabeth,Blackwood [9]
;
Scott E,Martin [12]
;
William F,Forrest [13]
;
James A,Ernst [13]
;
Chudi,Ndubaku [13]
;
Xiaojing,Wang [14]
;
Maureen H,Beresini [1]
;
Vickie,Tsui [13]
;
Carsten,Schwerdtfeger [8]
;
Robert A,Blake [4]
;
Jeremy,Murray [4]
;
Till,Maurer [5]
;
Ingrid E,Wertz [4]
作者单位：
Department of Discovery Oncology, Genentech, South San Francisco, California 94080, USA.
[1]
Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA.
[2]
Department of Structural Biology, Genentech, South San Francisco, California 94080, USA.
[3]
Department of Discovery Chemistry, Genentech, South San Francisco, California 94080, USA.
[4]
Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California 94080, USA.
[5]
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
[6]
Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 1HH, UK.
[7]
Department of Protein Chemistry, Genentech, South San Francisco, California 94080, USA.
[8]
Department of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, California 94080, USA.
[9]
Boston Biochem, 840 Memorial Drive, Cambridge, Massachusetts 02139, USA.
[10]
Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California, San Francisco, San Francisco, California 94143, USA.
[11]
Department of Research Pathology, Genentech, South San Francisco, California 94080, USA.
[12]
Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, California 94080, USA.
[13]
Department of Translational Oncology, Genentech, South San Francisco, California 94080, USA.
[14]
主题词
氨基吡啶类(Aminopyridines);动物(Animals);结合, 竞争性(Binding, Competitive);细胞系, 肿瘤(Cell Line, Tumor);药物协同作用(Drug Synergism);女(雌)性(Female);人类(Humans);吲唑类(Indazoles);小鼠(Mice);小鼠, SCID(Mice, SCID);模型, 分子(Models, Molecular);肿瘤(Neoplasms);酚类(Phenols);蛋白质结合(Protein Binding);原癌基因蛋白质c-mdm2(Proto-Oncogene Proteins c-mdm2);原癌基因蛋白质c-pim-1(Proto-Oncogene Proteins c-pim-1);吡啶类(Pyridines);底物特异性(Substrate Specificity);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);泛素(Ubiquitin)
DOI
10.1038/nature24006
PMID
29045385
发布时间
2022-03-21
- 浏览37
Nature
Nature
534-538页
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