Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice.

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作者： Ryan S,Tonkin ^[1] ; Callum,Bowles ^[1] ; Chamini J,Perera ^[1] ; Brooke A,Keating ^[1] ; Preet G S,Makker ^[1] ; Samuel S,Duffy ^[1] ; Justin G,Lees ^[1] ; Collin,Tran ^[2] ; Anthony S,Don ^[3] ; Thomas,Fath ^[1] ; Lu,Liu ^[1] ; Simon J,O'Carroll ^[4] ; Louise F B,Nicholson ^[4] ; Colin R,Green ^[5] ; Catherine,Gorrie ^[6] ; Gila,Moalem-Taylor ^[7]

作者单位： School of Medical Sciences, Faculty of Medicine, University of New South Wales, UNSW Sydney, NSW 2052, Australia. ^[1] Centenary Institute, University of Sydney Medical School, Sydney, NSW 2006, Australia. ^[2] Centenary Institute, University of Sydney Medical School, Sydney, NSW 2006, Australia; NHMRC Clinical Trials Centre, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia. ^[3] Department of Anatomy and Medical Imaging and the Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1142, New Zealand. ^[4] Department of Ophthalmology and New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1142, New Zealand. ^[5] School of Life Sciences, Faculty of Science, University of Technology, Sydney, NSW 2007, Australia. ^[6] School of Medical Sciences, Faculty of Medicine, University of New South Wales, UNSW Sydney, NSW 2052, Australia. Electronic address: gila@unsw.edu.au. ^[7]

关键词 ATP Connexins Gap junctions Hemichannels Inflammasome Nerve injury Neuropathic pain