Optimization of Substrate-Analogue Furin Inhibitors.

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作者： Teodora,Ivanova ^[1] ; Kornelia,Hardes ^[1] ; Stephanie,Kallis ^[2] ; Sven O,Dahms ^[3] ; Manuel E,Than ^[4] ; Sebastian,Künzel ^[5] ; Eva,Böttcher-Friebertshäuser ^[4] ; Iris,Lindberg ^[6] ; Guan-Sheng,Jiao ^[7] ; Ralf,Bartenschlager ^[8] ; Torsten,Steinmetzer ^[9]

作者单位： Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, 35032, Marburg, Germany. ^[1] Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, 69120, Heidelberg, Germany. ^[2] German Center for Infection Research, Heidelberg Partner Site, Im Neuenheimer Feld 345, 69120, Heidelberg, Germany. ^[3] Protein Crystallography Group, Leibniz Institute on Aging-Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany. ^[4] Department of Molecular Biology, University of Salzburg, Billrothstrasse 11, 5020, Salzburg, Austria. ^[5] Faculty of Engineering Sciences, Hochschule Ansbach, Residenzstraße 8, 91522, Ansbach, Germany. ^[6] Institute of Virology, Philipps University, Hans-Meerwein-Str. 2, Marburg, Germany. ^[7] Department of Anatomy and Neurobiology, University of Maryland Medical School, Baltimore, MD, 21201, USA. ^[8] Department of Chemistry, Hawaii Biotech, Inc., Honolulu, HI, USA. ^[9] MedChem ShortCut LLC, Pearl City, HI, USA. ^[10]

关键词 antiviral activity enzyme kinetics furin inhibitors proprotein convertases toxicity