Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes.

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作者： Kinga,Oravecz ^[1] ; Anita,Kormos ^[1] ; Andrea,Gruber ^[1] ; Zoltán,Márton ^[1] ; Zsófia,Kohajda ^[2] ; Leila,Mirzaei ^[1] ; Norbert,Jost ^[3] ; Jouko,Levijoki ^[4] ; Piero,Pollesello ^[4] ; Tuula,Koskelainen ^[4] ; Leena,Otsomaa ^[4] ; András,Tóth ^[1] ; Julius Gy,Papp ^[3] ; Péter P,Nánási ^[5] ; Gudrun,Antoons ^[6] ; András,Varró ^[7] ; Károly,Acsai ^[2] ; Norbert,Nagy ^[2]

作者单位： Department of Pharmacology and Pharmacotherapy, University of Szeged, Faculty of Medicine, Szeged, Hungary. ^[1] MTA-SZTE Research Group of Cardiovascular Pharmacology, Szeged, Hungary. ^[2] Department of Pharmacology and Pharmacotherapy, University of Szeged, Faculty of Medicine, Szeged, Hungary; MTA-SZTE Research Group of Cardiovascular Pharmacology, Szeged, Hungary. ^[3] Orion Pharma, Espoo, Finland. ^[4] Department of Physiology, University of Debrecen, Debrecen, Hungary. ^[5] Department of Cardiology, Medical University Graz, Austria; Department of Physiology, Maastricht University, Netherlands. ^[6] Department of Pharmacology and Pharmacotherapy, University of Szeged, Faculty of Medicine, Szeged, Hungary; MTA-SZTE Research Group of Cardiovascular Pharmacology, Szeged, Hungary. Electronic address: varro.andras@med.u-szeged.hu. ^[7]

关键词 Ca(2+) handling Cardiac inotropy NCX inhibition ORM-10962