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PQR309 Is a Novel Dual PI3K/mTOR Inhibitor with Preclinical Antitumor Activity in Lymphomas as a Single Agent and in Combination Therapy.

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第一作者： Chiara,Tarantelli

第一单位： Università della Svizzera Italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.

作者： Chiara,Tarantelli ^[1] ; Eugenio,Gaudio ^[1] ; Alberto J,Arribas ^[1] ; Ivo,Kwee ^[2] ; Petra,Hillmann ^[3] ; Andrea,Rinaldi ^[1] ; Luciano,Cascione ^[4] ; Filippo,Spriano ^[1] ; Elena,Bernasconi ^[1] ; Francesca,Guidetti ^[1] ; Laura,Carrassa ^[5] ; Roberta Bordone,Pittau ^[6] ; Florent,Beaufils ^[7] ; Reto,Ritschard ^[8] ; Denise,Rageot ^[7] ; Alexander,Sele ^[9] ; Barbara,Dossena ^[10] ; Francesca Maria,Rossi ^[11] ; Antonella,Zucchetto ^[11] ; Monica,Taborelli ^[10] ; Valter,Gattei ^[11] ; Davide,Rossi ^[4] ; Anastasios,Stathis ^[6] ; Georg,Stussi ^[6] ; Massimo,Broggini ^[5] ; Matthias P,Wymann ^[9] ; Andreas,Wicki ^[8] ; Emanuele,Zucca ^[6] ; Vladimir,Cmiljanovic ^[3] ; Doriano,Fabbro ^[3] ; Francesco,Bertoni ^[12]

作者单位： Università della Svizzera Italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland. ^[1] Università della Svizzera Italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.;Dalle Molle Institute for Artificial Intelligence (IDSIA), Manno, Switzerland.;Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland. ^[2] PIQUR Therapeutics AG, Basel, Switzerland. ^[3] Università della Svizzera Italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.;Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland. ^[4] IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. ^[5] Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland. ^[6] PIQUR Therapeutics AG, Basel, Switzerland.;Department of Biomedicine, University of Basel, Basel, Switzerland. ^[7] Department of Oncology, University Hospital Basel, Basel, Switzerland. ^[8] Department of Biomedicine, University of Basel, Basel, Switzerland. ^[9] Cytogenetics Laboratory, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. ^[10] Clinical and Experimental Onco-Hematology Unit, IRCCS-Centro di Riferimento Oncologico, Aviano, Italy. ^[11] Università della Svizzera Italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland. frbertoni@mac.com.;Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland. ^[12]