Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation.

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第一作者： Hui,Xie

第一单位： The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou 510120, China.

作者： Hui,Xie ^[1] ; Shaogao,Zeng ^[2] ; Yuwen,He ^[1] ; Guicheng,Zhang ^[2] ; Pengjiu,Yu ^[1] ; Guifa,Zhong ^[2] ; Hongjiang,Xu ^[3] ; Ling,Yang ^[3] ; Shanchun,Wang ^[3] ; Xin,Zhao ^[4] ; Wenhui,Hu ^[5]

作者单位： The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou 510120, China. ^[1] Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kaiyuan Avenue, Guangzhou 510530, China. ^[2] Jiangsu Chia-Tai Tianqing Pharmaceutical Co. Ltd, No. 8 Julong North Rd., Xinpu Lianyungang, Jiangsu 222006, China. ^[3] Key Laboratory of Molecular Clinical Pharmacology, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China. Electronic address: zhaoxin@gzhmu.edu.cn. ^[4] Key Laboratory of Molecular Clinical Pharmacology, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kaiyuan Avenue, Guangzhou 510530, China. Electronic address: huwenhui@gzhmu.edu.cn. ^[5]

关键词 DPP-4 inhibitor In?vivo efficacy Long-acting SAR Type 2 diabetes