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Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.

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第一作者： Matthias,Sendler

第一单位： Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.

作者： Matthias,Sendler ^[1] ; Frank-Ulrich,Weiss ^[1] ; Janine,Golchert ^[2] ; Georg,Homuth ^[2] ; Cindy,van den Brandt ^[1] ; Ujjwal M,Mahajan ^[3] ; Lars-Ivo,Partecke ^[4] ; Paula,Döring ^[5] ; Ilya,Gukovsky ^[6] ; Anna S,Gukovskaya ^[6] ; Preshit R,Wagh ^[1] ; Markus M,Lerch ^[1] ; Julia,Mayerle ^[7]

作者单位： Department of Medicine A, University Medicine Greifswald, Greifswald, Germany. ^[1] Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. ^[2] Medizinische Klinik und Poliklinik II, Universitätsklinikum der Ludwig-Maximilians-Universität, Klinikum Grosshadern, Munich, Germany. ^[3] Department of Surgery, University Medicine Greifswald, Greifswald, Germany. ^[4] Institute of Pathology, University Medicine Greifswald, Greifswald, Germany. ^[5] VA Greater Los Angeles Healthcare System; David Geffen School of Medicine, University of California at Los Angeles, California. ^[6] Department of Medicine A, University Medicine Greifswald, Greifswald, Germany; Medizinische Klinik und Poliklinik II, Universitätsklinikum der Ludwig-Maximilians-Universität, Klinikum Grosshadern, Munich, Germany. Electronic address: julia.mayerle@med.uni-muenchen.de. ^[7]

关键词 Immune Response Mechanisms Mouse Model Pancreatic Inflammation

医学主题词过继转移(Adoptive Transfer);动物(Animals);组织蛋白酶B(Cathepsin B);组织蛋白酶L(Cathepsin L);细胞, 培养的(Cells, Cultured);共同培养技术(Coculture Techniques);细胞因子类(Cytokines);疾病模型, 动物(Disease Models, Animal);胞吞作用(Endocytosis);酶激活(Enzyme Activation);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);氢离子浓度(Hydrogen-Ion Concentration);炎症介导素类(Inflammation Mediators);巨噬细胞(Macrophages);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);NF-κB(NF-kappa B);坏死(Necrosis);胰腺(Pancreas);胰腺切除术(Pancreatectomy);胰腺炎, 急性坏死性(Pancreatitis, Acute Necrotizing);吞噬作用(Phagocytosis);表型(Phenotype);疾病严重程度指数(Severity of Illness Index);时间因素(Time Factors);胰蛋白酶原(Trypsinogen)

DOI 10.1053/j.gastro.2017.10.018

PMID 29079517

发布时间 2023-11-12

基金项目

P01 DK098108/DK/NIDDK NIH HHS/United States I01 BX004306/BX/BLRD VA/United States IK6 BX005793/BX/BLRD VA/United States R01 AA019730/AA/NIAAA NIH HHS/United States P50 AA011999/AA/NIAAA NIH HHS/United States I01 BX000774/BX/BLRD VA/United States

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