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Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.

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第一作者： Manuel A,Ferreira

第一单位： Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

作者： Manuel A,Ferreira ^[1] ; Judith M,Vonk ^[2] ; Hansjörg,Baurecht ^[3] ; Ingo,Marenholz ^[4] ; Chao,Tian ^[5] ; Joshua D,Hoffman ^[6] ; Quinta,Helmer ^[7] ; Annika,Tillander ^[8] ; Vilhelmina,Ullemar ^[8] ; Jenny,van Dongen ^[7] ; Yi,Lu ^[8] ; Franz,Rüschendorf ^[9] ; Jorge,Esparza-Gordillo ^[4] ; Chris W,Medway ^[10] ; Edward,Mountjoy ^[10] ; Kimberley,Burrows ^[10] ; Oliver,Hummel ^[9] ; Sarah,Grosche ^[4] ; Ben M,Brumpton ^[11] ; John S,Witte ^[12] ; Jouke-Jan,Hottenga ^[7] ; Gonneke,Willemsen ^[7] ; Jie,Zheng ^[10] ; Elke,Rodríguez ^[3] ; Melanie,Hotze ^[3] ; Andre,Franke ^[13] ; Joana A,Revez ^[1] ; Jonathan,Beesley ^[1] ; Melanie C,Matheson ^[14] ; Shyamali C,Dharmage ^[14] ; Lisa M,Bain ^[1] ; Lars G,Fritsche ^[15] ; Maiken E,Gabrielsen ^[15] ; Brunilda,Balliu ^[16] ; 23andMe Research Team ^[17] ; AAGC collaborators ^[18] ; BIOS consortium ^[19] ; LifeLines Cohort Study ^[20] ; Jonas B,Nielsen ^[15] ; Wei,Zhou ^[21] ; Kristian,Hveem ^[22] ; Arnulf,Langhammer ^[23] ; Oddgeir L,Holmen ^[24] ; Mari,Løset ^[25] ; Gonçalo R,Abecasis ^[26] ; Cristen J,Willer ^[27] ; Andreas,Arnold ^[1] ; Georg,Homuth ^[1] ; Carsten O,Schmidt ^[28] ; Philip J,Thompson ^[29] ; Nicholas G,Martin ^[30] ; David L,Duffy ^[31] ; Natalija,Novak ^[32] ; Holger,Schulz ^[33] ; Stefan,Karrasch ^[5] ; Christian,Gieger ^[9] ; Konstantin,Strauch ^[3] ; Ronald B,Melles ^[8] ; David A,Hinds ^[34] ; Norbert,Hübner ^[33] ; Stephan,Weidinger ^[4] ; Patrik K E,Magnusson ^[7] ; Rick,Jansen ^[35] ; Eric,Jorgenson ^[8] ; Young-Ae,Lee ^[36] ; Dorret I,Boomsma ^[10] ; Catarina,Almqvist ; Robert,Karlsson ; Gerard H,Koppelman ; Lavinia,Paternoster

作者单位： Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. ^[1] Epidemiology, University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands. ^[2] Department of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. ^[3] Max Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.;Clinic for Pediatric Allergy, Experimental and Clinical Research Center of Charité Universitätsmedizin Berlin and Max Delbrück Center, Berlin, Germany. ^[4] Research, 23andMe, Mountain View, California, USA. ^[5] Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA. ^[6] Department of Biological Psychology, Netherlands Twin Register, Vrije University, Amsterdam, the Netherlands. ^[7] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. ^[8] Max Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany. ^[9] MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK. ^[10] MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.;K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;Department of Thoracic Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. ^[11] Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA. ^[12] Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany. ^[13] Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. ^[14] K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. ^[15] Department of Pathology, Stanford University School of Medicine, Stanford, California, USA. ^[16] Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.;Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. ^[17] Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. ^[18] K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. ^[19] HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. ^[20] K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. ^[21] K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. ^[22] K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.;Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.;Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. ^[23] Clinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany. ^[24] Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany. ^[25] Institute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald, Greifswald, Germany. ^[26] Institute for Respiratory Health, Harry Perkins Institute of Medical Research, University of Western Australia, Nedlands, Western Australia, Australia. ^[27] Department of Dermatology and Allergology, University Hospital Bonn, Bonn, Germany. ^[28] Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany. ^[29] Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany.;Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany. ^[30] Research Unit of Molecular Epidemiology and Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. ^[31] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. ^[32] Division of Research, Kaiser Permanente Northern California, Oakland, California, USA. ^[33] Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands. ^[34] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.;Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. ^[35] University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Pediatric Pulmonology and Pediatric Allergology, and University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands. ^[36]