首页> Genes & development> Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program.

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program.

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第一作者： Anna E,Mazzucco

第一单位： Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

作者： Anna E,Mazzucco ^[1] ; Agata,Smogorzewska ^[2] ; Chanhee,Kang ^[3] ; Ji,Luo ^[4] ; Michael R,Schlabach ^[5] ; Qikai,Xu ^[1] ; Rupesh,Patel ^[1] ; Stephen J,Elledge ^[1]

作者单位： Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. ^[1] Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.;Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.;The Rockefeller University, New York, New York 10065, USA. ^[2] Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.;School of Biological Sciences, Seoul National University, Seoul 08826, South Korea. ^[3] Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.;Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. ^[4] Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.;KSQ Pharmaceuticals, Cambridge, Massachusetts 02139, USA. ^[5]

关键词 GATA4 USP28 senescence