Characterization of Hydrophilic Gold(I) N-Heterocyclic Carbene (NHC) Complexes as Potent TrxR Inhibitors Using Biochemical and Mass Spectrometric Approaches.
第一作者:
Özden,Karaca
第一单位:
Molecular Catalysis, Department of Chemistry, Catalysis Research Center, Technische Universität München , Lichtenbergstraße 4, 85747 Garching bei München, Germany.;School of Chemistry, Cardiff University , Park Place, CF103AT Cardiff, U.K.
作者:
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);配位络合物(Coordination Complexes);DNA(DNA);药物稳定性(Drug Stability);G四链体(G-Quadruplexes);谷胱甘肽还原酶(Glutathione Reductase);金(Gold);人类(Humans);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);配体(Ligands);有机金化合物(Organogold Compounds);大鼠(Rats);活性氧(Reactive Oxygen Species);银(Silver);溶解度(Solubility);硫氧还蛋白还原酶1(Thioredoxin Reductase 1);硫氧还蛋白还原酶2(Thioredoxin Reductase 2)
DOI
10.1021/acs.inorgchem.7b02345
PMID
29095609
发布时间
2018-03-13
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Inorganic chemistry
14237-14250页
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