Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition.

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作者： Yu,Cai ^[1] ; Guanqun,Huang ^[2] ; Lijie,Ma ^[3] ; Ling,Dong ^[1] ; She,Chen ^[4] ; Xizhong,Shen ^[1] ; Shuncai,Zhang ^[1] ; Ruyi,Xue ^[5] ; Deqiang,Sun ^[6] ; Si,Zhang ^[7]

作者单位： Department of Gastroenterology and Hepatology, Zhongshan Hospital, Shanghai Institute of Liver Disease, Fudan University, Shanghai, China. ^[1] The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong Province, China. ^[2] Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China. ^[3] Key Laboratory of Glycoconjugate Research Ministry of Public Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China. ^[4] Department of Gastroenterology and Hepatology, Zhongshan Hospital, Shanghai Institute of Liver Disease, Fudan University, Shanghai, China. Electronic address: xue.ruyi@zs-hospital.sh.cn. ^[5] Institute of Biosciences & Technology, College of Medicine, Texas A&M University, Houston, TX, USA. Electronic address: dsun@tamu.edu. ^[6] Key Laboratory of Glycoconjugate Research Ministry of Public Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: zhangsi@fudan.edu.cn. ^[7]

关键词 Phosphodiesterase Smurf2 Ubiquitination cAMP miR-132

主题词动物(Animals);结缔组织生长因子(Connective Tissue Growth Factor);环核苷酸磷酸二酯酶类, 4型(Cyclic Nucleotide Phosphodiesterases, Type 4);女(雌)性(Female);人类(Humans);肝硬化(Liver Cirrhosis);男(雄)性(Male);小鼠(Mice);微RNAs(MicroRNAs);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis);信号传导(Signal Transduction);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.1016/j.bbamcr.2017.10.011

PMID 29100790

发布时间 2019-10-23

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Biochimica et biophysica acta. Molecular cell research

2018年1865卷2期

297-308页

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Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition.

Biochimica et biophysica acta. Molecular cell research

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Biochimica et biophysica acta. Molecular cell research

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Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition.

Biochimica et biophysica acta. Molecular cell research

相似文献

Biochimica et biophysica acta. Molecular cell research

相关期刊

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