Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response.

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第一作者： Michael A,Washington

第一单位： Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.

作者： Michael A,Washington ^[1] ; Stephen C,Balmert ^[2] ; Morgan V,Fedorchak ^[3] ; Steven R,Little ^[4] ; Simon C,Watkins ^[5] ; Tara Y,Meyer ^[6]

作者单位： Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA. ^[1] Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA. ^[2] Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15260, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA; Fox Center for Vision Restoration, University of Pittsburgh, Pittsburgh, PA 15260, USA. ^[3] Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA. ^[4] Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA; Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15260, USA. ^[5] Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: tmeyer@pitt.edu. ^[6]

关键词 Acidic microclimate Foreign body response Poly(lactic-co-glycolic acid)Sequenced copolymers Two-photon microscopy