Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease.

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作者： Sultan,Chaudhury ^[1] ; Tulsi,Patel ^[1] ; Imelda S,Barber ^[1] ; Tamar,Guetta-Baranes ^[1] ; Keeley J,Brookes ^[1] ; Sally,Chappell ^[1] ; James,Turton ^[1] ; Rita,Guerreiro ^[2] ; Jose,Bras ^[2] ; Dena,Hernandez ^[3] ; Andrew,Singleton ^[3] ; John,Hardy ^[4] ; David,Mann ^[5] ; ARUK Consortium ^[6] ; Kevin,Morgan

作者单位： Human Genetics Group, University of Nottingham, Nottingham, UK. ^[1] Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK; Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal; UK Dementia Research Institute at UCL (UK DRI), London, UK. ^[2] Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD, USA. ^[3] Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK; UK Dementia Research Institute at UCL (UK DRI), London, UK. ^[4] Faculty of Medical and Human Sciences, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK. ^[5] Human Genetics Group, University of Nottingham, Nottingham, UK. Electronic address: kevin.morgan@nottingham.ac.uk. ^[6]

关键词 Genotyping NeuroChip NeuroX Polygenic risk score (PRS)Sporadic early-onset Alzheimer's disease (sEOAD)