Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration.

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作者： Catherine Wenhui,Goh ^[1] ; Irene Chengjie,Lee ^[2] ; Jeyapriya Rajameenakshi,Sundaram ^[2] ; Simi Elizabeth,George ^[3] ; Permeen,Yusoff ^[2] ; Matthew Hayden,Brush ^[4] ; Newman Siu Kwan,Sze ^[5] ; Shirish,Shenolikar ^[6]

作者单位： Signature Research Programs in Neuroscience and Behavioural Disorders, Singapore 169857, Singapore. ^[1] Signature Research Programs in Neuroscience and Behavioural Disorders, Singapore 169857, Singapore; Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore. ^[2] Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore. ^[3] Ontology Development group, Oregon Health and Science University, Portland, Oregon 97239. ^[4] School of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore. ^[5] Signature Research Programs in Neuroscience and Behavioural Disorders, Singapore 169857, Singapore; Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore; Department of Psychiatry and Behavioral Sciences and Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710. Electronic address: Shirish.Shenolikar@Duke-NUS.edu.sg. ^[6]

关键词 CK1 GADD34 TAR DNA-binding protein 43 (TDP-43) (TARDBP)casein kinase 1?oxidation oxidative stress phosphoprotein phosphatase 1 (PP1)phosphorylation protein-protein interaction