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Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action.

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第一作者： Susan P,Felter

第一单位： Procter and Gamble, Central Product Safety, Mason, OH, United States. Electronic address: Felter.sp@pg.com.

作者： Susan P,Felter ^[1] ; Jennifer E,Foreman ^[2] ; Alan,Boobis ^[3] ; J Christopher,Corton ^[4] ; Adriana M,Doi ^[5] ; Lynn,Flowers ^[6] ; Jay,Goodman ^[7] ; Lynne T,Haber ^[8] ; Abigail,Jacobs ^[9] ; James E,Klaunig ^[10] ; Angela M,Lynch ^[11] ; Jonathan,Moggs ^[12] ; Arun,Pandiri ^[13]

作者单位： Procter and Gamble, Central Product Safety, Mason, OH, United States. Electronic address: Felter.sp@pg.com. ^[1] ExxonMobil Biomedical Sciences, Inc., Annandale, NJ, United States. ^[2] Department of Medicine, Imperial College London, London, UK. ^[3] National Health and Environmental Effects Research Lab, US EPA, Durham, NC, United States. ^[4] BASF Corporation, Research Triangle Park, NC, United States. ^[5] Office of Science Policy, US EPA, Washington DC, United States. ^[6] Michigan State University, Dept. Pharmacology and Toxicology, East Lansing, MI, United States. ^[7] Risk Science Center, Dept. of Environmental Health, University of Cincinnati, Cincinnati, OH, United States. ^[8] Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States. ^[9] Indiana University, Bloomington, IN, United States. ^[10] ToxPlus Consulting, LLC, Haymarket, VA, United States. ^[11] Novartis Institutes for BioMedical Research, Preclinical Safety, Translational Medicine, Basel, Switzerland. ^[12] National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States. ^[13]

关键词 Constitutive Androstane Receptor Mode of action Nongenotoxic Peroxisome proliferator-activated receptor alpha (PPARα)Rodent liver tumors