Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.

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作者： Antonio,Cuadrado ^[1] ; Sebastian,Kügler ^[2] ; Isabel,Lastres-Becker ^[3]

作者单位： Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Investigación Sanitaria La Paz (IdiPaz), Instituto de Investigaciones Biomédicas Alberto Sols UAM-CSIC, Madrid, Spain; Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, Spain. Electronic address: antonio.cuadrado@uam.es. ^[1] Department of Neurology, Center Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), University Medicine Göttingen, Göttingen, Germany. Electronic address: sebastian.kuegler@med.uni-goettingen.de. ^[2] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Investigación Sanitaria La Paz (IdiPaz), Instituto de Investigaciones Biomédicas Alberto Sols UAM-CSIC, Madrid, Spain; Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, Spain. Electronic address: ilbecker@iib.uam. ^[3]

关键词 DMF Inflammation NRF2 Neurodegeneration Oxidative stress TAU/ GSK-3

主题词动物(Animals);疾病模型, 动物(Disease Models, Animal);糖原合成酶激酶3(Glycogen Synthase Kinase 3);小鼠(Mice);分子靶向治疗(Molecular Targeted Therapy);NF-E2相关因子2(NF-E2-Related Factor 2);神经保护药(Neuroprotective Agents);氧化性应激(Oxidative Stress);信号传导(Signal Transduction);Tau病变(Tauopathies)

DOI 10.1016/j.redox.2017.10.010

PMID 29121589

发布时间 2021-01-09

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Redox biology

2018年14卷

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Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.

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Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.

Redox biology

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Redox biology

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