Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol efflux.

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作者： Liang,Chen ^[1] ; Qiying,Yao ^[2] ; Siwei,Xu ^[1] ; Hongyan,Wang ^[1] ; Peng,Qu ^[3]

作者单位： Department of Cardiology, Institute of Heart and Vascular Diseases, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. ^[1] Department of Physiology, School of Basic Medical Science, Dalian Medical University, Dalian, Liaoning, China. ^[2] Department of Cardiology, Institute of Heart and Vascular Diseases, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. Electronic address: qupeng7777@126.com. ^[3]

关键词 Atherosclerosis Foam cell formation Macrophage NLRP3 inflammasome

主题词胆固醇(Cholesterol);泡沫细胞(Foam Cells);人类(Humans);炎性体(Inflammasomes);脂蛋白类, LDL(Lipoproteins, LDL);巨噬细胞(Macrophages)

DOI 10.1016/j.bbrc.2017.11.025

PMID 29122594

发布时间 2018-12-02

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