首页> Matrix biology : journal of the International Society for Matrix Biology> Inducible knockdown of procollagen I protects mice from liver fibrosis and leads to dysregulated matrix genes and attenuated inflammation.

Inducible knockdown of procollagen I protects mice from liver fibrosis and leads to dysregulated matrix genes and attenuated inflammation.

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第一作者： Olena,Molokanova

第一单位： Institute of Translational Immunology, Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

作者： Olena,Molokanova ^[1] ; Kai,Schönig ^[2] ; Shih-Yen,Weng ^[1] ; Xiaoyu,Wang ^[1] ; Matthias,Bros ^[3] ; Mustafa,Diken ^[4] ; Svetlana,Ohngemach ^[5] ; Morten,Karsdal ^[6] ; Dennis,Strand ^[7] ; Alexei,Nikolaev ^[8] ; Leonid,Eshkind ^[5] ; Detlef,Schuppan ^[9]

作者单位： Institute of Translational Immunology, Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany. ^[1] Department of Molecular Biology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany. ^[2] Department of Dermatology, University Medical Center, Mainz, Germany. ^[3] Department for Immune Therapy Development, Translational Oncology, University Medical Center, Mainz, Germany. ^[4] Transgenic Facility Mainz, TARC, University Medical Center, Mainz, Germany. ^[5] Nordic Bioscience A/S, Herlev, Denmark. ^[6] Department of Medicine I, Mainz, Germany. ^[7] Institute of Molecular Medicine, University Medical Center, Mainz, Germany. ^[8] Institute of Translational Immunology, Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA. Electronic address: detlef.schuppan@unimedizin-mainz.de. ^[9]

关键词 Collagen Fibrosis Inducible Liver Procollagen I shRNA