Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase.

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作者： Małgorzata,Figiel ^[1] ; Miroslav,Krepl ^[2] ; Sangwoo,Park ^[3] ; Jarosław,Poznański ^[4] ; Krzysztof,Skowronek ^[5] ; Agnieszka,Gołąb ^[1] ; Taekjip,Ha ^[6] ; Jiří,Šponer ^[7] ; Marcin,Nowotny ^[8]

作者单位： Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland. ^[1] Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic; Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University Olomouc, 771 46 Olomouc, Czech Republic. ^[2] Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University, Baltimore, Maryland 21205. ^[3] Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland. ^[4] Biophysics Core Facility, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland. ^[5] Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University, Baltimore, Maryland 21205; Howard Hughes Medical Institute, Baltimore, Maryland 21205; Department of Biophysics, The Johns Hopkins University, Baltimore, Maryland 21205; Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21205. ^[6] Biophysics Core Facility, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland; Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University Olomouc, 771 46 Olomouc, Czech Republic. ^[7] Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland. Electronic address: mnowotny@iimcb.gov.pl. ^[8]

关键词 cysteine-mediated cross-linking human immunodeficiency virus (HIV)molecular dynamics nucleic acid structure protein-nucleic acid interaction reverse transcriptase ribonuclease H