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Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

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第一作者： Martin,Steger

第一单位： Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Martinsried, Germany.

作者： Martin,Steger ^[1] ; Federico,Diez ^[2] ; Herschel S,Dhekne ^[3] ; Pawel,Lis ^[2] ; Raja S,Nirujogi ^[2] ; Ozge,Karayel ^[1] ; Francesca,Tonelli ^[2] ; Terina N,Martinez ^[4] ; Esben,Lorentzen ^[5] ; Suzanne R,Pfeffer ^[3] ; Dario R,Alessi ^[2] ; Matthias,Mann ^[1]

作者单位： Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Martinsried, Germany. ^[1] Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom. ^[2] Department of Biochemistry, Stanford University School of Medicine, Stanford, United States. ^[3] The Michael J. Fox Foundation for Parkinson's Research, New York, United States. ^[4] Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. ^[5]

关键词 LRRK2 Parkinson's disease Rab GTPases biochemistry ciliogenesis human mass spectrometry mouse proteomics