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首页> European journal of medicinal chemistry> The Novel 4-Phenyl-2-Phenoxyacetamide Thiazoles modulates the tumor hypoxia leading to the crackdown of neoangiogenesis and evoking the cell death.

The Novel 4-Phenyl-2-Phenoxyacetamide Thiazoles modulates the tumor hypoxia leading to the crackdown of neoangiogenesis and evoking the cell death.

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作者： Yasser Hussein Eissa,Mohammed ^[1] ; Vikas H,Malojirao ^[2] ; Prabhu,Thirusangu ^[2] ; Mohammed,Al-Ghorbani ^[3] ; B T,Prabhakar ^[2] ; Shaukath Ara,Khanum ^[4]

作者单位： Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore 570005, Karnataka, India; Department of Biochemistry, Faculty of Applied Science College, University of Hajjah, Yemen. ^[1] Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science College (A), Kuvempu University, Shivamogga 577203, Karnataka, India. ^[2] Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore 570005, Karnataka, India. ^[3] Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore 570005, Karnataka, India. Electronic address: shaukathara@yahoo.co.in. ^[4]

关键词 HIF-1a Hypoxia Phenoxy acetic acid Thiazole Tumor microenvironment p53

主题词乙酰胺类(Acetamides);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞死亡(Cell Death);细胞增殖(Cell Proliferation);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);小鼠(Mice);分子结构(Molecular Structure);肿瘤, 实验性(Neoplasms, Experimental);新生血管化, 病理性(Neovascularization, Pathologic);大鼠(Rats);大鼠, Wistar(Rats, Wistar);构效关系(Structure-Activity Relationship);噻唑类(Thiazoles);肿瘤细胞, 培养的(Tumor Cells, Cultured)

DOI 10.1016/j.ejmech.2017.10.082

PMID 29133037

发布时间 2018-01-05

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European journal of medicinal chemistry

1826-1839页

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