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首页> European journal of medicinal chemistry> Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains.

Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains.

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第一作者： Ilija N,Cvijetić

第一单位： Innovation Center of the Faculty of Chemistry, University of Belgrade, Studentski trg 16, Belgrade, Serbia. Electronic address: ilija@chem.bg.ac.rs.

作者： Ilija N,Cvijetić ^[1] ; Tatjana Ž,Verbić ^[2] ; Pedro,Ernesto de Resende ^[3] ; Paul,Stapleton ^[3] ; Simon,Gibbons ^[3] ; Ivan O,Juranić ^[4] ; Branko J,Drakulić ^[4] ; Mire,Zloh ^[5]

作者单位： Innovation Center of the Faculty of Chemistry, University of Belgrade, Studentski trg 16, Belgrade, Serbia. Electronic address: ilija@chem.bg.ac.rs. ^[1] Faculty of Chemistry, University of Belgrade, Studentski trg 16, Belgrade, Serbia. ^[2] UCL School of Pharmacy, University College London, London, UK. ^[3] Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, University of Belgrade, Njegoševa 12, Belgrade, Serbia. ^[4] University of Hertfordshire, College Lane, Hatfield, AL10 9AB, UK. Electronic address: zloh@live.co.uk. ^[5]

关键词 3D QSAR Antimicrobial activity Aryl diketo acid Dehydrosqualene synthase Gram-positive Molecular docking Multidrug resistance

主题词抗菌药(Anti-Bacterial Agents);细菌(Bacteria);催化域(Catalytic Domain);药物设计(Drug Design);抗药性, 多药(Drug Resistance, Multiple);人类(Humans);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);酮酸类(Keto Acids);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2017.10.045

PMID 29133041

发布时间 2018-01-02

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European journal of medicinal chemistry

1474-1488页

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