Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer.

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第一作者： Andrea,Bistrović

第一单位： Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev Trg 20, HR-10000 Zagreb, Croatia.

作者： Andrea,Bistrović ^[1] ; Luka,Krstulović ^[2] ; Anja,Harej ^[3] ; Petra,Grbčić ^[3] ; Mirela,Sedić ^[3] ; Sanja,Koštrun ^[4] ; Sandra Kraljević,Pavelić ^[3] ; Miroslav,Bajić ^[2] ; Silvana,Raić-Malić ^[5]

作者单位： Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev Trg 20, HR-10000 Zagreb, Croatia. ^[1] Department of Chemistry and Biochemistry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000 Zagreb, Croatia. ^[2] Department of Biotechnology, Center for High-Throughput Technologies, University of Rijeka, Ulica Radmile Matejčić 2, HR-51000 Rijeka, Croatia. ^[3] Chemistry Department, Fidelta Ltd., Prilaz Baruna Filipovića 29, HR-10000 Zagreb, Croatia. ^[4] Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev Trg 20, HR-10000 Zagreb, Croatia. Electronic address: sraic@fkit.hr. ^[5]

关键词 1,2,3-triazole Benzimidazole Kinase Multitarget Non-small cell lung cancer (A549)p38 MAPK