Enhanced oral absorption and anticancer efficacy of cabazitaxel by overcoming intestinal mucus and epithelium barriers using surface polyethylene oxide (PEO) decorated positively charged polymer-lipid hybrid nanoparticles.
第一作者:
Tianyang,Ren
第一单位:
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China.
作者:
主题词
投药, 口服(Administration, Oral);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系(Cell Line);药物载体(Drug Carriers);人类(Humans);肠吸收(Intestinal Absorption);肠黏膜(Intestinal Mucosa);脂类(Lipids);肝肿瘤(Liver Neoplasms);男(雄)性(Male);小鼠(Mice);黏液(Mucus);纳米粒子(Nanoparticles);聚乙烯二醇类(Polyethylene Glycols);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);紫杉烷类(Taxoids);治疗结果(Treatment Outcome)
DOI
10.1016/j.jconrel.2017.11.015
PMID
29133120
发布时间
2022-03-30
- 浏览4
Journal of controlled release
423-438页
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