Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.

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作者： Carolyn D,Hurst ^[1] ; Olivia,Alder ^[1] ; Fiona M,Platt ^[1] ; Alastair,Droop ^[2] ; Lucy F,Stead ^[3] ; Julie E,Burns ^[1] ; George J,Burghel ^[4] ; Sunjay,Jain ^[5] ; Leszek J,Klimczak ^[6] ; Helen,Lindsay ^[4] ; Jo-An,Roulson ^[7] ; Claire F,Taylor ^[2] ; Helene,Thygesen ^[2] ; Angus J,Cameron ^[8] ; Anne J,Ridley ^[9] ; Helen R,Mott ^[10] ; Dmitry A,Gordenin ^[11] ; Margaret A,Knowles ^[12]

作者单位： Section of Molecular Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK. ^[1] Cancer Research UK Leeds Centre, Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK. ^[2] Section of Brain Tumour Research, Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK. ^[3] DNA Laboratory, Genetics Service, Ashley Wing, St James University Hospital, Beckett Street, Leeds LS9 7TF, UK. ^[4] Pyrah Department of Urology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK. ^[5] Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. ^[6] Department of Histopathology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK. ^[7] Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. ^[8] Randall Division of Cell and Molecular Biophysics, New Hunt's House, King's College London, Guy's Campus, London SE1 1UL, UK. ^[9] Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. ^[10] Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. ^[11] Section of Molecular Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK. Electronic address: m.a.knowles@leeds.ac.uk. ^[12]

关键词 KDM6A RHOB bladder cancer gender genomics mTORC1 metabolism recurrence-free survival subtypes