Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.-论文-万方医学网

第一作者： Petra,Steinacker

第一单位： Department of Neurology, University of Ulm, Ulm, Germany.

作者： Petra,Steinacker ^[1] ; Federico,Verde ^[2] ; Lubin,Fang ^[1] ; Emily,Feneberg ^[3] ; Patrick,Oeckl ^[1] ; Sigrun,Roeber ^[4] ; Sarah,Anderl-Straub ^[1] ; Adrian,Danek ^[5] ; Janine,Diehl-Schmid ^[6] ; Klaus,Fassbender ^[7] ; Klaus,Fliessbach ^[8] ; Hans,Foerstl ^[6] ; Armin,Giese ^[4] ; Holger,Jahn ^[9] ; Jan,Kassubek ^[1] ; Johannes,Kornhuber ^[10] ; G Bernhard,Landwehrmeyer ^[1] ; Martin,Lauer ^[11] ; Elmar Hans,Pinkhardt ^[1] ; Johannes,Prudlo ^[12] ; Angela,Rosenbohm ^[1] ; Anja,Schneider ^[13] ; Matthias L,Schroeter ^[14] ; Hayrettin,Tumani ^[1] ; Christine A F,von Arnim ^[1] ; Jochen,Weishaupt ^[1] ; Patrick,Weydt ^[13] ; Albert C,Ludolph ^[1] ; Deniz,Yilmazer Hanke ^[1] ; Markus,Otto ^[1] ; FTLDc study group

作者单位： Department of Neurology, University of Ulm, Ulm, Germany. ^[1] Department of Neurology, University of Ulm, Ulm, Germany.;Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.;Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. ^[2] Department of Neurology, University of Ulm, Ulm, Germany.;Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. ^[3] Center for Neuropathology and Prion Research, Ludwig-Maximilians University Munich, Munich, Germany. ^[4] Department of Neurology, Ludwig-Maximilians Universitat, Munich, Germany. ^[5] Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany. ^[6] Department of Neurology, Saarland University, Homburg/Saar, Germany. ^[7] Department of Psychiatry and Psychotherapy, Universityof Bonn, Bonn, Germany.;German Center for Neurodegenerative Diseases, Bonn, Germany. ^[8] Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[9] Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Munich, Germany. ^[10] Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany. ^[11] German Center for Neurodegenerative Diseases, Bonn, Germany.;Departmant of Neurology, Rostock University Medical Center, Rostock, Germany. ^[12] German Center for Neurodegenerative Diseases, Bonn, Germany.;Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany. ^[13] Clinic for Cognitive Neurology, University Clinic Leipzig, Leipzig, Germany.;Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. ^[14]

主题词老年人(Aged);阿尔茨海默病(Alzheimer Disease);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);病例对照研究(Case-Control Studies);克-亚综合征(Creutzfeldt-Jakob Syndrome);疾病恶化(Disease Progression);女(雌)性(Female);额颞叶变性(Frontotemporal Lobar Degeneration);己糖胺酶类(Hexosaminidases);人类(Humans);中间丝(Intermediate Filaments);巨噬细胞(Macrophages);男(雄)性(Male);小神经胶质细胞(Microglia);中年人(Middle Aged);帕金森病(Parkinson Disease);锥体束(Pyramidal Tracts);疾病严重程度指数(Severity of Illness Index);脊髓(Spinal Cord);存活率(Survival Rate)

DOI 10.1136/jnnp-2017-317138

PMID 29142138

发布时间 2019-07-03

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Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.

Journal of neurology, neurosurgery, and psychiatry

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Journal of neurology, neurosurgery, and psychiatry

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Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.

Journal of neurology, neurosurgery, and psychiatry

相似文献

Journal of neurology, neurosurgery, and psychiatry

相关期刊

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