Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.

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作者： Yukino,Hatazawa ^[1] ; Yusuke,Ono ^[2] ; Yuma,Hirose ^[3] ; Sayaka,Kanai ^[4] ; Nobuharu L,Fujii ^[5] ; Shuichi,Machida ^[2] ; Ichizo,Nishino ^[1] ; Takahiko,Shimizu ^[6] ; Masaki,Okano ^[7] ; Yasutomi,Kamei ^[8] ; Yoshihiro,Ogawa ^[9]

作者单位： Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. ^[1] Laboratory of Molecular Nutrition, Graduate School of Environmental and Life Science, Kyoto Prefectural University, Kyoto, Japan. ^[2] Japan Society for the Promotion of Science, Tokyo, Japan. ^[3] Musculoskeletal Molecular Biology Research Group, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. ^[4] Division of Regenerative Medicine Research, Japan Agency for Medical Research and Development (AMED), Tokyo, Japan. ^[5] Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Hachioji, Japan. ^[6] Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. ^[7] National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. ^[8] Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. ^[9] Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan. ^[10] Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; and. ^[11] Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Tokyo, Japan. ^[12]

关键词 DNA methylation atrophy epigenetics knockout mouse